Taurine prodrugs: amino acid anti-inflammatory drug devoid gastric toxicity.
Abstract
It is estimated that exists more than 50 different non steroidal anti-inflammatory drugs (NSAIDs) in the
market, but none of them are wholly without side effects such as gastro toxicity, even newer compounds,
selective to COX2 (cyclooxygenase-2) receptors, as the celecoxib. For this reason none of NSAIDs is
recommended for use in chronic inflammatory diseases. Taurine is reported to possess high antioxidant
activity, including intestinal anti-inflammatory activity. With this knowledge, we synthetized new antiinflammatory
mutual prodrug from classical NSAIDs (naproxen, diclofenac, salicylic acid, ibuprofen
and indomethacin) with taurine. The results showed protection of taurine in NSAIDs treated animals.
In a physical mixture of NSAIDs with taurine only taurine promote an decreased on the number of the
stomach ulcers compared to NSAID alone in all animals and all prodrugs obtained showed no gastric
toxicity. This indicate that taurine can protect gastric toxic effect from NSAID therapy and its use as a
carrier of NSAID is a new class of anti-inflammatory drug devoid gastro toxicity.
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